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Nelfinavir mesylate

CAS No. 159989-65-8

Nelfinavir mesylate ( AG-1343 mesylate )

Catalog No. M12296 CAS No. 159989-65-8

A potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM; exhibits an antiviral EC50 of 30 nM in HIV-1 strain RF-infected CEM-SS cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 67 In Stock
25MG 141 In Stock
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Biological Information

  • Product Name
    Nelfinavir mesylate
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM; exhibits an antiviral EC50 of 30 nM in HIV-1 strain RF-infected CEM-SS cells.
  • Description
    A potent and orally bioavailable HIV-1 protease inhibitor with Ki of 2 nM; exhibits an antiviral EC50 of 30 nM in HIV-1 strain RF-infected CEM-SS cells; also inhibits the proliferation of NSCLC cells, as well as every cell line in the NCI60 cell line panel with mean GI50 of 5.2 uM, induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.HIV Infection Approved
  • Synonyms
    AG-1343 mesylate
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIVprotease
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    159989-65-8
  • Formula Weight
    663.89
  • Molecular Formula
    C33H49N3O7S2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1=C(C=CC=C1O)C(=O)N[C@@H](CSC2=CC=CC=C2)[C@@H](CN3C[C@H]4CCCC[C@H]4C[C@H]3C(=O)NC(C)(C)C)O.CS(=O)(=O)O
  • Chemical Name
    3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)-, methanesulfonate (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang KE, et al. Antimicrob Agents Chemother. 2001 Apr;45(4):1086-93.
2. Shetty BV, et al. Antimicrob Agents Chemother. 1996 Jan;40(1):110-4.
3. Gills JJ, et al. Clin Cancer Res. 2007 Sep 1;13(17):5183-94.
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